High school chemistry teacher Skyler White learns she has terminal lung cancer. To secure her family’s future, she locates former student Jane Margolis, and the two begin producing and selling methamphetamine. As Skyler descends further into a life of crime and faces more and more difficult decisions, adopting the name “Heisenberg” for her second identity, she also has to avoid the watchful eyes of her sister Marie Schrader, a hardass DEA agent hellbent on discovering Heisenberg’s true identity. However, Marie isn’t even the worst of her problems - her boss and distributor Lydia Rodarte-Quayle, a calm, brilliant, extraordinarily successful drug kingpin, does not tolerate any mistakes. And Skyler’s partner Jane also has her own problems to deal with, like her addiction and the draw she feels toward the withdrawn girl she meets at rehab, Andrea Cantillo.